hOGG1, XRCC1 and XRCC3 polymorphisms influence micronucleus frequencies in human lymphocytes in vivo
نویسندگان
چکیده
Raluca A. Mateuca1,*,y, Mathieu Roelants, Gwenaelle Iarmarcovai3,y, Peter V. Aka1,y, Lode Godderis4,5,y, Annie Tremp, Stefano Bonassi, Michael Fenech, Jean-Louis Bergé-Lefranc8,y and Micheline Kirsch-Volders Laboratorium voor Cellulaire Genetica, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussel, Belgium, Laboratorium voor Antropogenetica, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussel, Belgium, Laboratoire de Biogénotoxicologie et Mutagenèse Environnementale (EA 1784; IFR PMSE 112), Faculté de Médecine, Université de la Méditerranée, Marseille, France, Laboratorium voor Arbeidshygiëne en -Toxicologie, Katholieke Universiteit Leuven, Kapucijnenvoer 35/6, 3000 Leuven, Belgium, IDEWE, Interleuvenlaan 58, 3001 Heverlee, Belgium, Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy, CSIRO Health Sciences and Nutrition, PO Box 10041, Adelaide, SA 5000, Australia and Laboratoire de Biochimie et Biologie Moléculaire, Hôpital de la Conception, 147 Boulevard Baille, 13385 Marseille cedex 5, France
منابع مشابه
DNA repair genes in endometriosis.
Several polymorphisms in the DNA repair gene are thought to have significant effects on cancer risk. We investigated the association of polymorphisms in the DNA repair genes XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys with endometriosis risk. Genotypes were determined by PCR-RFLP assays in 52 patients with endometriosis and 101 age-matche...
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متن کاملXRCC1 and XRCC3 DNA repair gene polymorphisms in breast cancer women from the Lodz region of Poland.
AIM Genetic polymorphism in XRCC1 and XRCC3 genes may influence DNA repair capacity and, in turn, confer predisposition to breast cancer. MATERIAL AND METHODS In the present work the distribution of genotypes and frequency of alleles of the Arg194Trp and Arg399Gln polymorphism of XRCC1 and Trp241 Met polymorphism in XRCC3 in breast cancer women were analysed. Blood samples were obtained from ...
متن کاملGenetic polymorphisms of DNA repair genes XRCC1 and XRCC3 and risk of colorectal cancer in Chinese population.
AIM The distribution of DNA repair gene XRCC1 and XRCC3 genotypes was used to assess the potential influence of genetic polymorphisms on risk of colorectal cancer, and interactions with other factors. METHODS A 1:2 matched case-control study was conducted with 485 cases and 970 controls. XRCC1 and XRCC2 genotype polymorphisms were based upon duplex polymerase-chain-reaction with the confronti...
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